I have used PayPal in the past for all sorts of transactions but not in the last few yearsI don't see anything about PayPal that makes me consider it more or less secure. Credit cards at least come with insurance if you can demonstrate fraud; neither debit cards or PayPal have this.
I never keep a credit balance in it, it's always auto filled from my credit card
The advantage of this is when PayPal denied any claims of mine in the past for say "non delivery" or "item not fit for purpose"
I have been able to get a refund from my credit card through charge back
I presume the same would apply to hotel bookings??