assuming there are no underground kinks ,blockages and the water flow is correctly running from the boiler into the return manifold.
are the circuits switched off. my rehau manifold has twist valves (red - plastic) that allow circuits to be switched on-off quickly.
are the actuators matched to the wrong circuits - try labelling them all and disconnecting them.
if the pipe runs are long , it might take a long time before you notice heat returning from the floor, that is quite normal.