We went there last October and having been to Paris, I reckon Rome is much easier to get around. But you have to WALK as you get to see all the sites. We stayed in the Savoy Hotel, not far from the American Embassy - some nice restaurants around there. Just be careful with pickpockets near the Trevi Fountain and the STEPS area. I saw a young local, I would think, lifting a wallet from an American Tourist and taking of at an incredible speed on foot!!!! Get one of those around the neck purses for your money and cards!! I bought one years ago for America and carry it abroad always!!!!
As the other poster said be clever about the restaurants, some of them are family run and even to sit inside listening to the "arguments" between husband and wife is great fun!!!! Food is good in those joints!!!! The Vatican is definitely worth a visit and if you want to see the Sistine Chapel, be prepared for a queue, but if you get there early in the morning, you will be OK. Watch the opening hours though, they are short!!! I guarantee you, you will never see in any other European country, the amount of Police in the city - traffic corps, and other types - all over the place! Real posers and shapers!!!! And the Italians are just what you see on the TV - colourful!!! Guaranteed you have more Men's boutiques than women, just watch out how the men dress! They LOVE their clothes!! I am hoping to go back at the end of the year!!! History is all around you and if you are interested in history, as we are, the saying SEE ROME AND DIE says it all! Visit the Pantheon - a remarkable feat of engineering!!!!
Enjoy!