If it is just a radiator replacement and there are no other issues with your heating system, i.e. circulation problems, sludge, etc. then there is no need to carry out a powerflush when replacing a radiator, especially if the only reason for replacement is a sizing issue.
If you are changing the radiator size from a single panel rad to an identical width one but double, then replacement is simple. If pipework needs to be extended to accommodate a wider radiator, then the system needs to be either drained for pipes frozen to install.
Make sure a decent inhibitor is put into the system either way such as Fernox F1.