I'm still on Win XP Pro but here's what I use:
- Avira personal (running)
- Sygate Personal Firewall (running)
- disable windows firewalll and windows defender
- CCleaner (periodically)
- Windows Disk Cleanup (periodically)
- Auslogics Disk Defrag (periodically)
- Malwarebytes' Anti-Malware (periodically) (beats Spybot, Adware hands down)
- online Panda Activescan or Trendmicro Housecall very rarely
and make use of Autoruns and Process Explorer
I still use Firefox as I use NoScript and Adblock Plus plugins - their brilliant.