It’s difficult to see about what you are worried. You have a diversified portfolio of investments, so you need to determine the performance of your overall portfolio and not just focus on one component. Then see if your portfolio has underperformed or overperformed the major indices (e.g. FTSE100, S&P, Eurostoxx, etc.) [which in today’s markets probably means has lost a lower amount this year]. I don’t see, based on what you have posted, what you are worried about; the fact that one of your components - the Iseq - has lost money is neither here nor there: it’s the performance of your overall portfolio relative to alternatives, e.g. major market indices, and associated risk that counts. God does not give a guarantee to investors that all investments will show a positive return all the time.