Think about this.
Construction
Outer concrete block
40 mm gap
60 mm polyiso type insulation
inner concrete block
25 mm polyiso type insulation
plasterboard
Any dampness, water that gets into or around your inner block will not be able to escape because of the polyiso on either side which is impenetrable to moisture. Moisture can rise up from poor workmanship on damp proof course at foundation level, leak around windows or items bridging cavity. Wind driven rain can penetrate plaster and outer block, move across cavity on ties etc etc. It just might make your inner block nice and warm and wet.
This is just my opinion. Would be much better to go for the larger cavity.
Also your internal leaf, concrete only, acts as a heat store during the day and releases it at night, if you insulate your wall internally you loose that.