How far inland does she want to go? We flew into Lyon with Aer Lingus last Sept/Oct, heading for Orange and Avignon. Orange is an hour & half down the autoroute, if you're hiring a car. I don't know about buses or trains though.
I'd highly recommend Orange, Arles and Avignon, as well as the vineyards of the Northern Provence (Gigondas, Vacqueras, Lirac, Tavel, etc). There are lots of wonderful rural hotels, guesthouses and B&Bs where the food & wine are amazing for a fraction of what you'd be charged for here in Ire.