Myself and my wife were in South Africa November 2004, we did the same trip (Kruger and Garden Route) and it was the best place we have ever visited - I'd love to go back. Kruger is a malarial zone and we took MALERONE - it is not available here, it has to be imported from UK, hence you get shafted for it price wise. It is not refundable from revenue, nor are the shots in the arm. We found Malerone good, no side effects (dizziness, sickness associated with others) and obviously no malaria! It is quite pricey though, but worth it for the piece of mind. From memory, you take it 1 or 2 days before entering the malaria zone, each day while there and 3 days or so after leaving (we were there for 5 days in total). We also used DEET to fend off any mozzies - apply it to your clothes, particularly at the feet where the mozzies tend to got for. Also, try and get some full length light weight trousers & a long sleeve T shirt, these will lessen the risk of bites on exposed areas particularly in the evening, avoid water sources (ponds, etc as they breed here) although there were not many about. The Garden Route (i.e. from Port Elizabeth to Cape Town) has 0% risk for malaria, it is much further south and the climate is milder. Bear in mind you are also advised to have shots (from memory, I had Thyphoid, yellow Fever, Hepatitis, &
Encephalitis shots - one set of 2 in each arm. I am a total wuss when it comes to needles, think it goes back to the hype around the BCG (remember that?) in primary school, but it was grand).
Any doubts, get medical advice. We got the whole lot (shots and Malerone) from the Tropical Medicine Bureau
www.tmb.ie, off Grafton Street in Dublin. Very good to deal with, know their stuff and staffed by suitably qualified people.