I did it in the ensuite and downstairs loo. A bit of modification had to be done to the waste pipes to get everything to fit.
We were tiling also and the mistake I made was not fitting everything before the tiling as you can't move any pipes after thats done. I had to get flexible piping to get the wastes to fit properly on the sinks but it's all hidden inside cabinets so it's not too bad. If you're just using a pedestal then you should definitely make sure that the waste pipes fit before tiling.
Other than that it's not difficult at all. Bit of patience is all thats required.