If you end up having to replumb the pipework, I strongly strongly recommend that you future proof your pipework, by getting the plumber to use 32mm pipes for each of the main runs. This will allow you to upgrade to a heat pump later without having to do any pipework.
Also, for any radiators that you are replacing (or new ones that you are putting in) size them up so that they are appropriate for a heat pump.
And also the new hot water cylinder, make sure the coil is compatible with a heat pump.
For a retrofit heat pump, the pipework and radiator upgrades are usually more than half the cost. Doing them now, will mean upgrading later will take a lot less time and cost a lot less money. It might cost a few hundred extra to do these upgrades now, but could save you thousands later.
You could also consider going straight to heat pump, (I'd definitely get at least a quote) but if you want to get the grant, you will likely need to upgrade the insulation and windows.