What matters is the codec you use. If you use Lame it will be better than the internal encoders that most applications use. Most don't come with Lame, which is free but you have to install it seperately. I use Audiograbber with Lame myself. EAC is meant to be the most accurate method.
I use MediaMonkey for playing and managing my music and love it. But it gives me random weird noise in anything I rip using it. Like static every so often. Probably just some conflict between my computer and MediaMonkey. No one else seems to have that problem.