In some areas, if you don't meet the requirements in the advertisement, then you are screened out immediately. That is particularly applicable to jobs funded out of the public purse. It is possible for a disappointed applicant to cause great trouble if somebody who did not satisfy the stated criteria gets the job.
In many other situations, the number of applicants might be so large that strict application of criteria is the first step to getting the number of applicants down to a manageable number.
But it's probably worth giving it a shot. Just don't get your hopes up too high.